For this story, WIRED reviewed dozens of NASA documents, including backup plans and contingencies for emergencies, and spoke to more than a dozen people, including three astronauts who’ve visited the ISS, and no one seemed that freaked out. One astronaut said the most worrisome scenario that actively crossed his mind in orbit was getting a toothache. The ISS has had some emergencies, including a first-ever medical evacuation in January, but generally things have been remarkably stable. In fact, one of the most impressive things about the ISS is that nothing very dramatic has ever happened to it. No experiment has gone too haywire. It hasn’t been hit by an asteroid.
Again, the answer to this question varies from company to company. And again, testing is the way to find out what works best. Typically, weekends and mornings seem to be times when multiple emails are opened, but since your audience may have different habits, it's best to experiment and then use your data to decide.
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